(8aR,9R)-9-Hydroxy-7,8,8a,9-tetrahydrofuro[3,2-f]indolizin-6(4H)-one
نویسندگان
چکیده
The title compound, C(10)H(11)NO(3), crystallizes with four independent mol-ecules in the asymmetric unit. Their geometries are very similar and corresponding bond distances are almost identical. The central six-membered ring of the indolizine moiety adopts a envelope conformation [the displacement of the flap atom (the C atom opposite the N atom) being 0.539 (2), 0.548 (3), 0.509 (3) and 0.544 (3) Å in the four molecules], while the conformation of the oxopyrrolidine ring is close to that of a flat envelope. The displacements of the non-fused C atom opposite the C=O group of the pyrrolidine ring of the four mol-ecules are 0.366 (3), 0.335 (3), 0.173 (3) and -0.310 (3) Å. In the crystal, O-H⋯O hydrogen bonds link the mol-ecules into chains, which run parallel to the c axis. The absolute configuration was assigned from the synthesis.
منابع مشابه
(8aS)-7,8,8a,9-Tetrahydrothieno[3,2-f]indolizin-6(4H)-one
In the mol-ecular structure of the title compound, C(10)H(11)NOS, the central six-membered ring of the indolizine unit adopts an envelope conformation, the maximum deviations from the mean plane of the ring being 0.533 (2) Å. The fused thieno ring is nearly coplanar [mean deviation = 0.007 (2) Å]. The conformation of the fused oxopyrrolidine ring is close to that of a flat-envelope, with a maxi...
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عنوان ژورنال:
دوره 68 شماره
صفحات -
تاریخ انتشار 2012